A02801 腺病毒HEXON抗原 Recombinant AdV HEXON(His Tag)

Source：

Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)

Cat.No.: 

A02801

Construction：

Ala2-Thr968

Tag:

His Tag

Molecular Mass：

110.39 kDa

Expression Host：

HEK293 cells

Formulation：

Purified, Liquid

Buffer：

Phosphate Buffered Saline,5%mannital,0.05% Tween20, pH7.4

Purification：

>95% pure (SDS-PAGE). 

Storage:

For long term storage, the product should be stored at -20°C or lower.

 

Please avoid repeated freeze-thaw cycles.

 

 

 

Description：

Adenoviruses (AdVs) are non-enveloped icosahedral viruses with a double-stranded DNA genome. Hexon is one of the three major structural proteins of the adenovirus capsid, whose hypervariable regions exhibit the sequence variability among adenovirus serotypes. Hexon is the most abundant structural proteins, with 240 copies of the trimeric molecule in the capsid, accounting for approximately 60% of the total protein mass. Hexon is a large polypeptide, more than 900 amino acids long in all known adenovirus types. The monomer folds as two eight-stranded β barrels, or jellyroll domains, held apart by a small β-sheet. The double jelly rolls form the pseudo-hexagonal base of the trimeric hexon capsomer. Long loops intercalated between the β-strands form the hexon towers, and contain the hyper variable regions (HVRs). The N-termini and C-termini adopt different conformations depending on their location in the capsid, to establish interactions between hexons and minor coat proteins IIIa and VIII. The architecture of hexon is highly conserved throughout the Adenoviridae family. The main differences reside in the HVRs, which present a varying degree of flexibility in the different virus types.

 

 

图1 腺病毒衣壳结构示意图

 

 

 

图2 Hexon结构示意图

 

 

 

 

 

 

 

 

参考文献：

[1] Rux JJ, et al. 2004. Hum Gene Ther. 15(12):1167-76.

[2] Gallardo J, et al. 2021. Int J Mol Sci. 22(10):5240.