C01907 甲流-甲型流感单抗 Flu A-mAb（Mouse，包被抗体）

Cat.No.: 

C01907

Source：

Monoclonal Mouse Antibody

Subtype：

mIgG2a/mK

Molecular Mass：

150 kDa

Expression Host：

HEK293 cells

Formulation：

Purified, Liquid

Buffer：

Phosphate Buffered Saline,5%mannital,0.05% Tween20, pH7.4

Purification：

>95% pure (SDS-PAGE). 

Storage:

For long term storage, the product should be stored at -20°C or lower.

 

Please avoid repeated freeze-thaw cycles.

 

 

 

Description：

Influenza is an infectious respiratory disease; in humans, it is caused by influenza A (genus influenzavirus A) and influenza B (genus influenzavirus B) viruses (influenzavirus C and influenzavirus D genera are also known).Influenza A virus (IAV) is a negative-stranded RNA virus. The IAV genome is divided into eight segments that encode 11 viral proteins in total (HA, NA, M1, M2, NP, NS1, NS2, PA, PB1, PB2, and PB1-F2). The viral envelope of IAV contains the transmembrane proteins HA, NA, and M2.

The IAV recognizes specific receptors expressed on the host cell surface using HA and enters cells via endocytosis. After fusion of the viral envelope and endosomal membrane, vRNPs are released into the cytoplasm and translocate into the nucleus to initiate replication. Newly synthesized vRNPs are exported to the cytoplasm, and assembly of progeny virions occurs near the plasma membrane. NA facilitates budding of new virions from host cells.

 

 

图1 甲型流感病毒的结构

 

 

 

图2 甲型流感病毒的复制过程

 

 

 

 

 

 

 

 

参考文献：

[1] Jung HE, Lee HK. 2020. Viruses. 12(5):504.

[2] Krammer F, et al. 2018. Nat Rev Dis Primers. 4(1):3.